I started on Anafranil two months ago. I'm on 75mg right now. Since I've been on it, I've only cried three times. I've only had a "panic attack" twice. I used to get depressed every week. I still get depressed sometimes, but not as often. My anxiety has gone down. There are times when I actually feel "happy" or "normal". I forgot what normal felt like... My sense of humor is back. I do more than just sit and mud all day. At times, I actually feel good about myself, and have what most people would call "self esteem". I suppose this all means that it's working for me...